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Paclitaxel

Paclitaxel

Paclitaxel is a natural substance derived from the yew tree by taking a naturally present substance from the tree and chemically altering it to form the drug. FZBIOTECH,as a manufacturer of monomer, has been devoting to supplying the best quality paclitaxel to all over the world with best price. Chat Now
Description

Basic Information of Paclitaxel Powder

Purity:98%, 99%
Appearance: White crystalline powder
CAS:33069-62-4
EINECS NO.: 205-285-7
Molecular Formula: C15H24N202
Molecular Weight: 264.36
Source: Root, branches and bark.


Introduction of Paclitaxel Powder

Paclitaxel is a natural substance derived from the yew tree by taking a naturally present substance from the tree and chemically altering it to form the drug. It is used as a chemotherapy drug to treat people with a wide variety of cancers.


Function of Paclitaxel Powder

Paclitaxel is now used to treat patients with lung, ovarian, breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxel is also used for the prevention of restenosis.
Paclitaxel stabilizes microtubules and as a result, interferes with the normal breakdown of microtubules during cell division. Together with docetaxel, it forms the drug category of the taxanes.


Package & Delivery

Delivery: Sea/ Air Shipping & International Express                                                                                  
Shipping Time: 2-3 working days after payment 
Package: 1-5kg/Aluminum foil bag, size: 22cm (Width)*32cm (Length)
             15-25kg/Drum, size: 38cm (Diameter)*50cm (Height)
Storage: Kept away from strong light and heat.                                                                                   
Shelf Life: 24 months

Paclitaxel.jpg


Paclitaxel.jpg


Certificate of Analysis

TEST ITEM

SPECIFICATION

RESULTS


Appearance

White or almost white crystalline powder

White crystalline Powder


 

Identification

FT-IR

Conform



HPLC

Conform



NMR

Conform



Mass

Conform


Solubility 

Soluble in ethanol,methanol,Chloroform,

hardly soluble in water

Conform


Specific Optical Rotation

-49.0°~ -55.0°at 20°C

-49.2°


Melting Point

213°C―216°C

213.2°C


Water

≦1.0%

0.42%


Residual Solvent

Meets the requirements of ICH

Conform


Ethyl Acetate

≦5000ppm

300ppm


Acetone

≦5000ppm

300ppm


Methanol

≦3000ppm

320ppm


Acetic acid

≦5000ppm

400ppm


Residual of volatile Solvents

Meets the requirements of ICH

Conform


Chloroform

≦60ppm

Absence


Dichloromethane

≦600ppm

5ppm


Hexane

≦290ppm

70ppm


Toluene

≦890ppm

5ppm






Residue on Ignition

≦0.2%

≦0.12%


Bacteria endotoxins

≦0.4USP EU/mg

0.15EU/mg


Microbial Limits




Total aerobic microbial count

≦100cfu/g

60cfu/g


Staphylococcus aureus

Absence

Absence


Pseudomonas aeruginosa

Absence

Absence


Salmonella species

Absence

Absence


Escherichia Coli

Absence

Absence


Heavy Metals

≦20ppm

10ppm


IMPURITIES:




10-Deacetyl Baccatin Ⅲ

≦0.1%

0.00%


Baccatin Ⅲ

≦0.2%

0.00%


Photodegradant

≦0.1%

0.00%


10- Deacetyl Paclitaxel

≦0.5%

0.03%


2-Debenzoylpaclitaxel-2-pente noate

≦0.7%

0.08%


Oxetane ring opened,Acetyl 

and benzoyl

x1

≦0.1%

0.00%

10-Acetoacetyl paclitaxel

x2

≦0.1%

0.00%

10-Deacetyl-7-epi-paclitaxel

x3

≦0.3%

0.01%


(x1+x+2x3)

≦0.4%

0.01%

7-epi-paclitaxel

≦0.4%

0.09%


10,13-Bissidechainpaclitaxel

≦0.5%

0.00%


7-Acetyl Paclitaxel

≦0.6%

0.02%


13-Tes-Baccatin Ⅲ

≦0.1%

0.00%


7-Tes-Paclitaxel

≦0.3%

0.00%


Any other single impurity

≦0.1%

0.04%max


Total Impurities

≦2.0%

0.33%


Assay(HPLC)

98.5%-102%

99.67%


CONCLUSION

The lot meets the specifications.




Company Image

Paclitaxel.jpg


Paclitaxel.jpg




Xi'an Fengzu Biological Technology Co.,Ltd is one of the professional China paclitaxel manufacturers, for all you needs of best, price, organic, 100% pure, nature, and GMP factory paclitaxel, please feel free to contact us. And welcome to wholesale bulk and high quantity paclitaxel, paclitaxel injection, carboplatin paclitaxel, paclitaxel 99%, paclitaxel api, 33069-62-4, 205-285-7, c15h24n202, paclitaxel powder from us.

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Xi'an Fengzu Biological Technology Co.,Ltd
Manufacturer Add: Industrial Park in Wugong County, Xianyang City,Shaanxi Province, China.
Office Add: 21F, Tangfengguoji,No.18 Fenghuinanlu, Xi'an City, Shaanxi Province, China.
Office Tel: 86-029-89561932/86-135-7248-9476             Office Fax: 86-029-8918-9705
Email: sales@fengzusw.com                                            Skype: fengzusw