Home > Knowledge > Content

Products

Contact Us

Name: Mr.Alex

Tel: 86-29-8918-1410

86-187-0910-6130

Email: sales@fengzusw.com

Skype: fengzusw

WhatsApp: +86-135-7241-4292

The Benefit of Tranexamic Acid

The Benefit of Tranexamic Acid
Tranexamic acid is a synthetic derivative of the amino acid lysine that exerts its antifibrinolytic effect through the reversible blockade of lysine binding sites on plasminogen molecules. Intravenously administered tranexamic acid (most commonly 10 mg/kg followed by infusion of 1 mg/kg/hour) caused reductions relative to placebo of 29 to 54% in postoperative blood losses in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB), with statistically significant reductions in transfusion requirements in some studies.

Tranexamic acid had similar efficacy to aprotinin 2 x 10(6) kallikrein inhibitory units (KIU) and was superior to dipyridamole in the reduction of postoperative blood losses. Transfusion requirements were reduced significantly by 43% with tranexamic acid and by 60% with aprotinin in 1 study. Meta-analysis of 60 trials showed tranexamic acid and aprotinin, unlike epsilon-aminocaproic acid (EACA) and desmopressin, to reduce significantly the number of patients requiring allogeneic blood transfusions after cardiac surgery with CPB.

Tranexamic acid was associated with reductions relative to placebo in mortality of 5 to 54% in patients with upper gastrointestinal bleeding. Meta-analysis indicated a reduction of 40%. Reductions of 34 to 57.9% versus placebo or control in mean menstrual blood loss occurred during tranexamic acid therapy in women with menorrhagia; the drug has also been used to good effect in placental bleeding, postpartum haemorrhage and conisation of the cervix.

Tranexamic acid significantly reduced mean blood losses after oral surgery in patients with haemophilia and was effective as a mouthwash in dental patients receiving oral anticoagulants. Reductions in blood loss were also obtained with the use of the drug in patients undergoing orthotopic liver transplantation or transurethral prostatic surgery, and rates of rebleeding were reduced in patients with traumatic hyphaema. Clinical benefit has also been reported with tranexamic acid in patients with hereditary angioneurotic oedema. Tranexamic acid is well tolerated; nausea and diarrhoea are the most common adverse events. Increased risk of thrombosis with the drug has not been demonstrated in clinical trials.

Where to buy tranexamic acid?

You may have deep understanding of tranexamic acid. Xi'an Fengzu Biological Techology Co.,Ltd., as a professional supplier of plant extract and monomer, has been devoting to providing various pure plant extract and monomer with favorable price. You can send E-mail to sales@fengzusw.com directly for a competitive price and professional knowledge. For long time cooperation, free samples is available. We're looking forward your inquiry.

 

]
Xi'an Fengzu Biological Technology Co.,Ltd
Manufacturer Add: Industrial Park in Wugong County, Xianyang City,Shaanxi Province, China.
Office Add: 21F, Tangfengguoji,No.18 Fenghuinanlu, Xi'an City, Shaanxi Province, China.
Office Tel: 86-029-89561932/86-135-7248-9476             Office Fax: 86-029-8918-9705
Email: sales@fengzusw.com                                            Skype: fengzusw