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Healthcare Product-Soy Isoflavone

Soy isoflavone are polyphenolic compounds that are capable of exerting estrogen-like effects. For this reason, they are classified as phytoestrogens—plant-derived compounds with estrogenic activity. Legumes, particularly soybeans, are the richest sources of isoflavones in the human diet. In soybeans, isoflavones are present as glycosides (bound to a sugar molecule). Fermentation or digestion of soybeans or soy products results in the release of the sugar molecule from the isoflavone glycoside, leaving an isoflavone aglycone. Soy isoflavone glycosides are called genistin, daidzin, and glycitin, while the aglycones are called genistein, daidzein, and glycitein. Unless otherwise indicated, quantities of isoflavones specified in this article refer to aglycones—not glycosides.


The biological effects of soy isoflavones are strongly influenced by their metabolism, which is dependent on the activity of bacteria that colonize the human intestine. For example, the soy isoflavone daidzein may be metabolized in the intestine to equol, a metabolite that has greater estrogenic activity than daidzein, and to other metabolites that are less estrogenic. Studies that measure urinary equol excretion after soy consumption indicate that only about 33% of individuals from Western populations metabolize daidzein to equol. Thus, individual differences in the metabolism of isoflavones could have important implications for the biological activities of these phytoestrogens.


Soy isoflavones and their metabolites also have biological activities that are unrelated to their interactions with estrogen receptors. By inhibiting the synthesis and activity of certain enzymes involved in estrogen metabolism, soy isoflavones may alter the biological activity of endogenous estrogens and androgens. Soy isoflavones have also been found to inhibit tyrosine kinases, enzymes that play critical roles in the signaling pathways that stimulate cell proliferation. Additionally, isoflavones can act as antioxidants in vitro, but the extent to which they contribute to the antioxidant status of humans is not yet clear. Plasma F2-isoprostanes, biomarkers of lipid peroxidation in vivo, were significantly lower after two weeks of daily consumption of soy protein containing 56 mg of isoflavones than after consumption of soy protein providing only 2 mg of isoflavones. However, daily supplementation with 50-100 mg of isolated soy isoflavones did not significantly alter plasma or urinary F2-isoprostane levels.


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Xi'an Fengzu Biological Technology Co.,Ltd
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