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Anticancer Paclitaxel

Introduction

Paclitaxel is a natural substance derived from the yew tree by taking a naturally present substance from the tree and chemically altering it to form the drug. Paclitaxel is a natural substance derived from the yew tree by taking a naturally present substance from the tree and chemically altering it to form the drug. The resultant drug is administered intravenously. It is used as a chemotherapy drug to treat people with a wide variety of cancers.

The History of Paclitaxel

Natural Paclitaxel is a mitotic inhibitor used in cancer chemotherapy. It was discovered in a National Cancer Institute program at the Research Triangle Institute in 1967 when Monroe E. Wall and Mansukh C. Wani isolated it from the bark of the Pacific yew tree, Taxus brevifolia and named it 'taxol'.

The Function of Paclitaxel

Paclitaxel is a mitotic inhibitor now used to treat patients with lung,ovarian,breast cancer, head and neck cancer, and advanced forms of Kaposi's sarcoma. Paclitaxel works by interfering with normal microtubule breakdown during cell division, Paclitaxel is also used for the prevention of restenosis. Together with docetaxel, it forms the drug category of the taxanes. It was the subject of a notable total synthesis by Robert A. Holton.

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