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High Quality 99% Lab Provide Topiroxostat/ FYX 051/ CAS 577778-58-6

High Quality 99% Lab Provide Topiroxostat/ FYX 051/ CAS 577778-58-6

Topiroxostat is a drug for the treatment of gout and hyperuricemia. It was approved for use in Japan in June 2013.Topiroxostat is a xanthine oxidase inhibitor which reduces serum urate levels. FZBIOTECH,as a manufacturer of monomer, has been devoting to supplying the best quality Benzothiophene powder to all over the world with best price.Chat Now

Basic Infromation of Topiroxostat /FYX 051

Product Name: Topiroxostat /FYX 051

Appearance: white powder 

Purity: 99.5% min 

Molecular formula: C13H8N6

Molar mass: 248.24 g/mol

Molecular weight: 248.24282

CAS: 577778-58-6


Structural Formula:


Introduction of Topiroxostat /FYX 051

Topiroxostat is an inhibitor of xanthine oxidoreductase (IC50 = 5.3 nM), an enzyme that converts xanthine to urate. Formulations containing topiroxostat are effective in vivo, lowering urate levels in the serum of patients with hyperuricemia. In rats, but not primates, topiroxostat treatment results in the formation of xanthine crystals, resulting in nephritis. Topiroxostat also inhibits ATP-binding cassette transporter G2 (ABCG2; IC50 = 0.18 μM), a high-capacity urate transporter that functions in both renal and extrarenal urate secretion.

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