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Cyproheptadine HCL/Cyproheptadine Hydrochloride Powder

Cyproheptadine HCL/Cyproheptadine Hydrochloride Powder

Cyproheptadine sold under the brand name Periactin or Peritol, is a first-generation antihistamine with additional anticholinergic, antiserotonergic, and local anesthetic properties.FZBIOTECH,as a manufacturer of monomer, has been devoting to supplying the best quality Cyproheptadine HCL powder to all over the world with best price. For long term cooperation, free sample is available.Chat Now
Description

Basic Information of Cyproheptadine Hydrochloride
Other Name:Cyproheptadine HCL,periactinsyrup
MF: C21H22ClN
MW: 323.86
Boiling Point:440.1ºC at 760mmHg
Purity:99%
CAS: 969-33-5
EINECS: 213-535-1
Structural Formula:
Cyproheptadine HCL.png
What is Cyproheptadine Hydrochloride?
Cyproheptadine is a serotonin and histamine antagonist with anticholinergic and sedative effects. Antiserotonin and antihistamine drugs appear to compete with serotonin and histamine, respectively, for receptor sites.


Benefits of Cyproheptadine Hydrochloride
Anticoagulant, anti-allergy drug class. Can be used for hives, eczema, atopic and contact dermatitis, pruritus and other allergic reactions. Urticaria, eczema, atopic and contact dermatitis, pruritus, rhinitis, migraine, bronchial asthma. Can also be used for Cushing's disease and acromegaly.
For the H1 receptor antagonists, more effective than chlorpheniramine, promethazine strong and moderate resistance to 5 - serotonin function and anticholinergic effects. In addition, clinical findings, a variety of new uses cyproheptadine, etc. As well as the treatment of mumps, studies have shown that cyproheptadine hydrochloride in H1 antagonism than five times stronger than chlorpheniramine.


COA of Cyproheptadine Hydrochloride


ItemsAcceptance criteriaResults
CharacterAppearance: White or almost white powder.Almost white powder
Solubility: Slightly soluble in water, freely
soluble in dilute acetic acid and in methanol,
slightly soluble in alcohol.
Complies
IdentificationA.Specific optical rotation: –30.0º~-33.5º
(dried substance)
–33.3º
B.Infrared absorption spectrophotometry:
The IR spectrum is consistent with that
obtained with Levodropropizine CRS.
Complies
TestspH9.2~10.29.4
Impurity B and related
substances
Impurity B: ≤ 0.5%≤ 0.1%
Any other impurity: ≤ 0.1 %≤ 0.1%
Total impurities: ≤ 0.6 %≤ 0.1%
Impurity C≤ 5 ppm≤ 5ppm
Enantiomeric purityImpurity A: ≤ 2 %0.2 %
Loss on drying≤ 1.0 %.≤ 0.1%
Sulphated ash≤ 0.2 %≤ 0.1%
Assay98.5%~ 101.0%(dried substance)99.7%
ConclusionThe product meets the specification of EP7.0


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