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Best Quality Rofecoxib,bulk Supply USP EP Rofecoxib

Best Quality Rofecoxib,bulk Supply USP EP Rofecoxib

Rofecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is classified as a nonsteroidal anti-inflammatory drug.FZBIOTECH,as a manufacturer of API, has been devoting to supplying the best quality rofecoxib to all over the world with best price. For long term cooperation, free sample is availablChat Now

Basic information of Rofecoxib

Product Name: Rofecoxib

CAS Number:162011-90-7

Molecular Formula:C17H14O4S

Molecular Weight:314.36

Appearance:White or milk white crystalline powder


Structural Formula:


Benefits of Rofecoxib

Rofecoxib is used for the treatment of osteoarthritis, rheumatoid arthritis, acute pain in adults, and primary dysmenorrhea, as well as acute treatment of migraine attacks with or without auras. Rofecoxib is a solid.

Rofecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is classified as a nonsteroidal anti-inflammatory drug (NSAID). Unlike celecoxib, rofecoxib lacks a sulfonamide chain and does not require CYP450 enzymes for metabolism. Like other NSAIDs, rofecoxib exhibits anti-inflammatory, analgesic, and antipyretic activity. NSAIDs appear to inhibit prostaglandin synthesis via the inhibition of cyclooxygenase (COX), which are responsible for catalyzing the formation of prostaglandins in the arachidonic acid pathyway. There are at least two isoenzymes, COX-1 and COX-2, that have been identified. Although the exact mechanisms have not been clearly established, NSAIDs exert their anti-inflammatory, analgesic, and antipyretic primarily through the inhibition of COX-2. The inhibition of COX-1 is principally responsible for the negative effects on the GI mucosa. As rofecoxib is selective for COX-2, it may be potentially associated with a decreased risk of certain adverse events, but more data is needed to fully evaulate the drug.

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Xi'an Fengzu Biological Technology Co.,Ltd
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